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Final overall survival (OS) results from the Phase III PAOLA-1/ENGOT-ov25 trial evaluating maintenance olaparib (ola) plus bevacizumab (bev) in patients (pts) with newly diagnosed advanced ovarian cancer (AOC) Presentation #LBA29. the phase 3 PAOLA-1 (PAOLA-1/ENGOT-ov25) trial, we evaluated maintenance therapy with a PARP inhibitor (olaparib) as compared with placebo in patients with newly diagnosed ad- Objectives: In the PAOLA -1/ENGOT-ov25 primary analysis (NCT02477644) , adding the PARP inhibitor olaparib to maintenance bevacizumab (bev) after first-line platinum-based chemotherapy with bev led to a significant progression-free survival (PFS) benefit vs placebo (pbo) + bev in patients (pts) with advanced high-grade PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for newly diagnosed advanced high-grade ovarian cancer demonstrated a significant progression-free survival (PFS) benefit over placebo plus bevacizumab, particularly in patients with homologous recombination deficiency (HRD)–positive tumors. 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Homologous Recombination Repair Gene Mutations to Predict Olaparib Plus Bevacizumab Efficacy in the First-Line Ovarian Cancer PAOLA-1/ENGOT-ov25 Trial January 2023 JCO Precision Oncology 7(7):e2200258 PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for newly diagnosed advanced high-grade ovarian cancer demonstrated a significant progression-free survival (PFS) benefit over placebo plus bevacizumab, particularly in patients with homologous recombination deficiency (HRD)–positive tumors. • In the PAOLA-1/ENGOT-ov25 trial (NCT02477644), the addition of maintenance olaparib (a PARPi) to bevacizumab led to prolonged progression-free survival (PFS) and overall survival (OS) vs placebo plus bevacizumab in patients with newly diagnosed AOC, specifically those who tested positive for homologousIn the Phase III PAOLA-1/ENGOT-ov25 (NCT02477644) trial, the addition of the PARP inhibitor olaparib to bevacizumab maintenance therapy led to a significant progression-free survival (PFS) benefit in patients with newly. PAOLA-1/ENGOT-ov25 (NCT02477644) demonstrated a significant progression-free survival (PFS) benefit with maintenance olaparib plus bevacizumab versus placebo plus bevacizumab in newly diagnosed, advanced ovarian cancer. PAOLA-1/ENGOT-ov25 trial evaluating maintenance olaparib plus bevacizumab in patients with newly diagnosed advanced ovarian cancer Isabelle Ray-Coquard,1 Alexandra Leary,2 Sandro Pignata,3 Claire Cropet,4 Antonio González-Martín,5 Gerhard Bogner,6 Hiroyuki Yoshida,7 Ignace Vergote,8With football prediction site like Victor Predict, victory is assured. 2:1. We offers Over 2. They offer you a wide array of correct predictions that you can rely on blindly. Criscione, PhD2; Andreas du Bois, MD3; Domenica Lorusso, MD4; Ignacio Romero, MD5; Edgar. 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